Toxicity and anti-inflammatory effects of Eleutherine bulbosa (Miller) Urb, ethanolic extract, in zebrafish (Danio rerio).

Introduction: Eleutherine bulbosa (Miller) Urb, popularly known as "marupa-zinho", is frequently used in traditional medicine for treating various diseases, including hypertension, ulcers, constipation, and intestinal infection. However, there is little scientific knowledge available regarding the pharmacological effects of this species. Thus in vivo and in silico phytochemical studies are required to establish whether this plant has these effects.

Health technology assessment in the Brazilian National Health System: profile of CONITEC exclusion recommendations, 2012-2023.

Objective: To analyze the recommendations for exclusion of health technologies in the Brazilian National Health System (SUS), made by the National Commission for the Incorporation of Technologies in the Brazilian National Health System (CONITEC) from 2012 to 2023, and to identify the disinvestment criteria used.

Methods: Documentary, descriptive and retrospective analysis of CONITEC reports that assessed technology exclusion requests.

Results: We identified 24 reports on 74 technologies, whereby the requests predominantly involved medications (95.

Immune Responses to Respiratory Syncytial Virus Vaccines: Advances and Challenges.

Respiratory Syncytial Virus (RSV) is a leading cause of acute respiratory infections, particularly in children and the elderly. This virus primarily infects ciliated epithelial cells and activates alveolar macrophages and dendritic cells, triggering an innate antiviral response that releases pro-inflammatory cytokines. However, immunity generated by infection is limited, often leading to reinfection throughout life.

Efficacy of xenogeneic collagen matrix in the treatment of gingival recessions: a controlled clinical trial.

This study aimed to evaluate the efficacy of a xenogeneic collagen matrix (XCM) in treating gingival recessions (GR) in a thin gingival phenotype. This double-blind, planned, controlled, split-mouth clinical trial included 30 patients with bilateral recessions, randomly assigned to a test group (extended flap + XCM) and a control group (extended flap + connective tissue graft; CTG). Root coverage at 18 months was 1.

Identification of targetable epigenetic vulnerabilities in uveal melanoma.

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, which preferentially metastasizes to the liver in approximately half of all cases. Metastatic UM is notoriously resistant to therapy and is almost uniformly fatal. UM metastasis is most strongly associated with mutational inactivation of the tumor suppressor gene.