Publications by authors named "S B van Waalwijk van Doorn-Khosrovani"
Precision oncology has a significant role to play in delivering optimal patient care. Biomarkers are critical enablers for precision oncology across the continuum of cancer diagnosis, in defining patient prognosis, and in predicting the response to treatments and their potential toxicities, as well as delineating the risk of hereditary cancer syndromes. Biomarkers also potentiate cancer drug development, accelerating patient access to safe and effective therapies.
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- * In a study with -ΔSRI mice, it was found that maternal intake of a genistein-rich diet led to increased oxidative DNA damage in the testes of male offspring, particularly in those with lower G6PDH activity.
- * The research concluded that prenatal exposure to genistein not only increased DNA damage but also altered gene expression related to oxidative stress, suggesting potential long-term effects on male reproductive health.
A balanced redox homeostasis in the testis is essential for genetic integrity of sperm. Reactive oxygen species can disturb this balance by oxidation of glutathione, which is regenerated using NADPH, formed by glucose-6-phosphate dehydrogenase (G6PDH). G6PDH is regulated by the Ataxia Telangiectasia Mutated (Atm) protein.
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