Publications by authors named "S B el Badawi"
Sentiment analysis is an essential task that involves the extraction, identification, characterization, and classification of textual data to understand and categorize the attitudes and opinions expressed by individuals. While other languages have extensive datasets in this field, the number of sentiment analysis datasets in the Kurdish language is extremely limited, highlighting the necessity to build datasets for the language to advance its development. This paper presents a Twitter dataset comprising 24,668 tweets from the initial sample of 30,009 texts.
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- * In healthy cells, the homologous recombination (HR) process for rDNA stability is similar to that in other parts of the genome but is disrupted in BLM-deficient cells.
- * Without Bloom helicase (BLM), rDNA can still attract RAD51, which causes genomic instability and micronuclei formation, indicating broader implications for genome integrity.
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- The study investigates the role of IL-6 and MCP-1 cytokines, along with the STAT3 signaling pathway, in recruiting and activating macrophages during heart attacks (STEMI) using both human and mouse models.
- Cardiac cells release these cytokines under low oxygen conditions, leading to the activation of anti-inflammatory macrophages through the STAT3 pathway.
- The research finds that blocking IL-6, MCP-1, or the STAT3 pathway can decrease heart damage after a heart attack, suggesting that these anti-inflammatory macrophages may have negative effects in the early stages of STEMI.
The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly folded, processed and assembled proteins to exit the ER and reach their functional destinations. Mutant proteins unable to attain their correct tertiary conformation or form complexes with their partners are retained in the ER and subsequently degraded through ER-associated protein degradation (ERAD) and associated mechanisms. ER retention contributes to a spectrum of monogenic diseases with diverse modes of inheritance and molecular mechanisms.
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- Myocardial infarction (MI) causes heart muscle damage due to blocked blood flow, leading to the production of reactive oxygen species and a redox imbalance, with myoglobin playing a key role in this process.
- The study introduces a new imaging method that uses advanced techniques to examine the oxidation-reduction states of myoglobin in heart tissue after MI, revealing how myoglobin's fluorescence can indicate the state of the myocardium.
- Findings show that the spectral properties of myoglobin in infarcted heart tissue correlate with infarct size, suggesting myoglobin's redox state could be a valuable biomarker for assessing MI severity in its early stages.