Attentional biases for dynamic stimuli in emerging adults with anxiety: A preliminary eye-tracking study.

While attentional biases towards negative stimuli have previously been linked to the development and maintenance of anxiety disorders, a current limitation of this research involves the use of static images for stimuli, as they cannot adequately depict the dynamic nature of real-life interactions. Since attentional biases in those with elevated anxiety remain understudied using more naturalistic stimuli, such as dynamic social videos, the purpose of this explorative study was to use novel dynamic stimuli and modern eye-tracking equipment to further investigate negative attentional biases in anxious emerging, female adults. Non-clinical participants (N = 62; mean age = 20.

Relationship Between Personality Traits and Emotional Impacts of the COVID-19 Pandemic on Canadian Emerging Adults.

We assessed whether traits from the four-factor vulnerability model for substance misuse are associated with the content of emotional descriptions given by Canadian university students of the impact of the COVID-19 pandemic on their lives. Personality traits were measured in 1185 first- and second-year undergraduates (mean age = 19.11 years; 79% female).

Ask, do not tell: consulting a patient advisory board to understand unmet needs of patients with GVHD in Europe.

Graft-versus-host disease (GVHD) is a complication of hematopoietic cell transplantation (HCT) that has a low chance of complete remission and a substantial effect on morbidity and mortality. To better understand how to improve the field of GVHD research, management, and care, the cGVHD Eurograft Initiative organised a European community advisory board of patient advocates, with the assistance of the Lymphoma Coalition, to identify unmet needs. We present the results of this project in this Viewpoint, which identify unmet GVHD needs from the patient advocates' perspectives and provide five key actionable themes to improve GVHD management and care.

A qualitative study of benzodiazepine/z-drug and opioid co-use patterns and overdose risk.

Background: Co-use of benzodiazepines and/or 'z-drugs' along with opioids is linked to the rise in drug related deaths (DRD) in the UK. Understanding patterns of co-use could inform harm reduction strategies for reducing DRDs. This study explored how people co-use, including dosages, timings, methods of administration, use of other substances and desired effects sought.

Tolerability Assessment of Orally Administered Paclitaxel With Encequidar in Dogs With Spontaneous Malignancy.

Paclitaxel is an antimitotic agent that targets elements of the cancer phenotype, including cell proliferation, DNA repair, and apoptosis, predicting its broad activity in a spectrum of cancers. An oral paclitaxel formulation has been developed to overcome challenges associated with parenteral administration of this drug, notably the development of Cremophor-induced acute hypersensitivity reactions, which are particularly problematic in dogs. The aim of this open-label, dose-escalating study was to evaluate the tolerability and determine the maximum tolerated dosage (MTD) and dose-limiting toxicity (DLT) of oral paclitaxel when co-administered with the P-glycoprotein pump inhibitor, encequidar, in dogs with cancer.