Publications by authors named "S B Sendi"
Article Synopsis
- The study investigates N-acetylcysteine (NAC) as a potential treatment for adults with treatment-resistant PTSD, focusing on its effects on oxidative stress in the brain.
- Conducted as a randomized, double-blind, placebo-controlled trial, participants received either 2.7 g/day of NAC or a placebo for 12 weeks, with outcomes measured at baseline and follow-up points.
- Results showed no significant difference in PTSD symptoms between NAC and placebo at week 12, but improvements in craving duration and resistance were noted at week 64 for those taking NAC.
Background: Enhanced post-awakening cortisol may serve as a biological marker for individuals with major depressive disorder. However, studies comparing post-awakening cortisol between patients with major depressive disorder (MDD) and healthy controls have produced conflicting findings. The aim of this study was to investigate whether this inconsistency could be due to the effects of childhood trauma.
View Article and Find Full Text PDFBackground: Technology has changed the landscape in which psychiatry operates. Effective, evidence-based treatments for mental health care are now available at the fingertips of anyone with Internet access. However, technological solutions for mental health are not necessarily sought by consumers nor recommended by clinicians.
View Article and Find Full Text PDFBackground: Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to the development of depression (major depressive disorder, MDD), but it is unclear whether neural effects observed in healthy individuals are sustained in MDD.
Aims: To investigate BDNF Val66Met effects on key regions in MDD neurocircuitry: amygdala, anterior cingulate, middle frontal and orbitofrontal regions.
Method: Magnetic resonance imaging scans were acquired in 79 persons with MDD (mean age 49 years) and 74 healthy volunteers (mean age 50 years).