PDGFRα inhibition reduces myofibroblast expansion in the fibrotic rim and enhances recovery after ischemic stroke.

Ischemic stroke is a major cause of adult disability. Early treatment with thrombolytics and/or thrombectomy can significantly improve outcomes; however, following these acute interventions, treatment is limited to rehabilitation therapies. Thus, the identification of therapeutic strategies that can help restore brain function in the post-acute phase remains a major challenge.

Coherent time- and wavelength-division multiplexed point-to-multipoint optical access network using low-cost DFB lasers enabled by a frequency comb.

Coherent reception, along with time- and wavelength-division multiplexing (TWDM), is a promising concept to simultaneously support multiple services in future high-speed point-to-multipoint passive optical networks (PONs). The next-generation PON 2 (NG-PON2) standard describes a TWDM-PON based on IM/DD intensity modulation and direct detection (IM/DD) which employs tunable-lasers and optical filters such as tunable optical filters or cyclic arrayed-waveguide gratings. Here, we investigate what we believe to be a novel coherent TWDM-PON architecture based on a frequency comb source in the optical line terminal (OLT), and thermally-tuned distributed-feedback (DFB) lasers in the optical network units (ONUs).

3D-printed facet-attached optical elements for connecting VCSEL and photodiodes to fiber arrays and multi-core fibers.

Multicore optical fibers and ribbons based on fiber arrays allow for massively parallel transmission of signals via spatially separated channels, thereby offering attractive bandwidth scaling with linearly increasing technical effort. However, low-loss coupling of light between fiber arrays or multicore fibers and standard linear arrays of vertical-cavity surface-emitting lasers (VCSEL) or photodiodes (PD) still represents a challenge. In this paper, we demonstrate that 3D-printed facet-attached microlenses (FaML) offer an attractive path for connecting multimode fiber arrays as well as individual cores of multimode multicore fibers to standard arrays of VCSEL or PD.

3D-printed facet-attached optical elements for beam shaping in optical phased arrays.

We demonstrate an optical phased-array equipped with a 3D-printed facet-attached element for shaping and deflection of the emitted beam. The beam shaper combines freeform refractive surfaces with total-internal-reflection mirrors and is in-situ printed to edge-emitting waveguide facets using high-resolution multi-photon lithography, thereby ensuring precise alignment with respect to on-chip waveguide structures. In a proof-of-concept experiment, we achieve a grating-lobe free steering range of ±30 and a full-width-half-maximum beam divergence of approximately 2.

Ultra-fast optical ranging using quantum-dash mode-locked laser diodes.

Laser-based light detection and ranging (LiDAR) is key to many applications in science and industry. For many use cases, compactness and power efficiency are key, especially in high-volume applications such as industrial sensing, navigation of autonomous objects, or digitization of 3D scenes using hand-held devices. In this context, comb-based ranging systems are of particular interest, combining high accuracy with high measurement speed.