Publications by authors named "S B REES"
Dysregulation of choline phospholipid metabolism and overexpression of phosphatidylcholine-specific phospholipase C (PC-PLC) is implicated in various cancers. Current known enzyme inhibitors include compounds based on a 2-morpholino-5--benzylamino benzoic acid, or hydroxamic acid, scaffold. In this work, 81 compounds were made by modifying this core structure to explore the pharmacophore.
View Article and Find Full Text PDFAim: Acute myocarditis (AM) is increasingly diagnosed in the era of more sensitive imaging techniques. The natural history of AM diagnosed on cardiac magnetic resonance imaging (cMRI) may be different to historic cohorts due to the detection of milder disease. This study aims to measure the outcome of patients with AM detected by cMRI.
View Article and Find Full Text PDFArticle Synopsis
- Federated networks enhance data privacy by allowing analysis without transferring sensitive data, supporting trustworthy data analysis in healthcare research.
- The International COVID-19 Data Alliance (ICODA) tested a federated network with partners to analyze data from the International Perinatal Outcome in the Pandemic (iPOP) Study, facing both challenges and benefits in the process.
- Establishing these networks requires significant investment and planning for technology and governance, which can lead to powerful collaborative research opportunities using health data from various countries.
Background: Acute respiratory distress syndrome (ARDS) is highly heterogeneous, both in its clinical presentation and in the patient's physiological responses to changes in mechanical ventilator settings, such as PEEP. This study investigates the clinical efficacy of a physiological model-based ventilatory decision support system (DSS) to personalize ventilator therapy in ARDS patients.
Methods: This international, multicenter, randomized, open-label study enrolled patients with ARDS during the COVID-19 pandemic.