Publications by authors named "S B Parfenuyk"
Article Synopsis
- The review highlights type 1 diabetes (T1D) as a systemic autoimmune and inflammatory disease, emphasizing the role of the innate immune system in its development.
- The dysfunction of innate immunity leads to the destruction of pancreatic beta cells by T-lymphocytes, resulting in insulin deficiency and subsequent hyperglycemia, which poses risks to various organs and tissues.
- The review discusses the potential of antioxidants, especially the enzyme peroxiredoxin 6, to mitigate oxidative stress and promote insulin production, thereby potentially reducing the harmful effects associated with T1D.
Taking into account a special role of pancreatic β-cells in the development of diabetes mellitus, the effects of peroxiredoxin 6 (Prx6) on the viability and functional activity of rat insulinoma RIN-m5F β-cells were studied under diabetes-simulating conditions. For this purpose, the cells were cultured at elevated glucose concentrations or in the presence of pro-inflammatory cytokines (TNF-α and IL-1) known for their special role in the cytotoxic autoimmune response in diabetes. It was found that the increased glucose concentration of 23-43 mM caused death of 20-60% β-cells.
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