Publications by authors named "S B Karch"
RICTOR is a key component of the mTORC2 signaling complex which is involved in the regulation of cell growth, proliferation and survival. RICTOR is highly expressed in neurons and is necessary for brain development. Here, we report eight unrelated patients presenting with intellectual disability and/or development delay and carrying variants in the RICTOR gene.
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- The study examines how Parkinson's disease (PD) medication affects cognitive functioning, psychiatric symptoms, impulsivity, and quality of life in patients with advanced PD who are preparing for deep brain stimulation surgery.
- It compares effects of low versus high dosages of levodopa-equivalent dosage (LED) and the presence or absence of dopamine agonists on neuropsychological performance.
- Results indicate that lower LED correlates with better performance in impulsivity tests and that dopamine agonists can negatively impact verbal learning tasks and increase psychiatric symptoms, suggesting the need for careful consideration before surgery.
Article Synopsis
- The study involved 15 PC patients participating in an 8-week intervention of cognitive training and group therapy, while a control group of 15 PC patients underwent assessments without participation to measure cognitive performance.
- Findings showed significant improvements in many cognitive areas for the intervention group, particularly in verbal memory and visuo-spatial skills, supporting the idea that structured group therapy and cognitive training can be beneficial for PC patients dealing with cognitive issues.
Quantum gas microscopes have revolutionized quantum simulations with ultracold atoms, allowing one to measure local observables and snapshots of quantum states. However, measurements so far were mostly carried out in the occupation basis. Here, we demonstrate how all kinetic operators, such as kinetic energy or current operators, can be measured and manipulated with single-bond resolution.
View Article and Find Full Text PDFEmotion dysregulation has long been considered a key symptom in multiple psychiatric disorders. Difficulties in emotion regulation have been associated with neural dysregulation in fronto-limbic circuits. Real-time fMRI-based neurofeedback (rt-fMRI-NFB) has become increasingly popular as a potential treatment for emotional dysregulation in psychiatric disorders, as it is able to directly target the impaired neural circuits.
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