Dexamethasone mimics aspects of physiological acclimatization to 8 hours of hypoxia but suppresses plasma erythropoietin.

Dexamethasone ameliorates the severity of acute mountain sickness (AMS) but it is unknown whether it obtunds normal physiological responses to hypoxia. We studied whether dexamethasone enhanced or inhibited the ventilatory, cardiovascular, and pulmonary vascular responses to sustained (8 h) hypoxia. Eight healthy volunteers were studied, each on four separate occasions, permitting four different protocols.

Chemical Examination of Citrus sinensis Flavedo Variety Pineapple.

Phytochemical examination of Citrus sinensis flavedo var. Pineapple resulted in the isolation of six compounds characterized as tetracosane, ethyl pentacosanoate, tetratriacontanoic acid, tangertin, beta-sitosteryl-beta-D-glucoside and 3,5,4'-trihydroxy-7,3'-dimethoxy flavanone 3-O-beta-glucoside. Of these 3,5,4'-trihydroxy-7,3'-dimethoxy flavanone 3-O-beta-glucoside is a hitherto unreported compound.

Chemical Investigation of Crataeva nurvala Buch. Ham. Fruits.

Chemical investigation of fruits of Crataeva nurvala has revealed the presence of four known compounds which are pentadecane, octanamide, 12-tricosanone and friedelin. These compounds have been characterized on the basis of spectral and other data. These are being reported for the first time from the fruits of this plant.

A New coumarin from Citrus paradisi Macf.

Phytochemical examination of the peel of grapefruit resulted in the isolation of five compounds namely friedelin, beta -sitosterol, 7(3',7',11',14'-tetramethy)pentadec-2',6',10'-trienyloxycoumarin, limonin and cordialin B. These compounds have been characterized on the basis of spectral data, and 7(3',7',11',14'-tetramethy)pentadec-2',6',10'-trienyloxycoumarin is a hitherto unreported compound.