Publications by authors named "S B Hanauer"
Article Synopsis
- - Gastrointestinal immune-related adverse events (GI irAEs) are a frequent issue linked to immune checkpoint inhibitors (ICIs), impacting various parts of the GI system, including the stomach, liver, and pancreas.
- - A systematic review was conducted using multiple databases, leading to the analysis of 166 studies focused on GI irAEs, examining their incidence, management strategies, and patient outcomes.
- - The review covers different types of GI toxicity related to ICIs, including upper GI (like esophagitis), lower GI (such as colitis), and other rare forms, aiming to provide clinicians with insights for better diagnosis and treatment.
Background And Aims: This systematic review aims to elucidate the use of corticosteroids in randomized clinical trials (RCTs) evaluating biologics and small molecules for inflammatory bowel disease (IBD). We analyzed corticosteroid use during both the induction and maintenance phases, highlighting areas needing standardization and improvement in clinical research.
Methods: We selected placebo-controlled phase 3 RCTs involving adults with moderate to severe IBD.
Clinical Trial Design Considerations for Hospitalised Patients With Ulcerative Colitis Flares and Application to Study Hyperbaric Oxygen Therapy in the NIDDK HBOT-UC Consortium.
Parambir S Dulai Lauren Balmert Bonner Charlotte Sadler Laura E Raffals Gursimran Kochhar Stephen B Hanauer
Aliment Pharmacol Ther
December 2024
Article Synopsis
- Patients with ulcerative colitis (UC) experiencing severe flares in the hospital are a unique and high-risk group requiring specialized clinical trial designs.
- A multi-centre consortium is developing a trial for hyperbaric oxygen therapy, addressing important factors like inclusion/exclusion criteria, disease activity measures, and tailored care pathways.
- The study highlights the need for comprehensive outcome measures and standardized care practices while emphasizing the significance of early intervention and statistical planning in these small clinical trials.