Surgical Repair of Double Outlet Right Ventricle Infants Guided by Three Dimensional-Computed Tomography Cardiac Modeling and Printing.

Background: Double outlet right ventricle (DORV) is a challenging congenital cardiac lesion to surgically master. We utilize computed tomography-guided-three-dimensional (3D) modeling/printing and novel in-house software to delineate anatomical relationships providing operative insight into the surgical approach. Our intent is to highlight this and showcase our technology.

Unconventional site of pacing for failed balloon valvotomy of prosthetic tricuspid valve: a case report.

Background: Conduction disturbances are a frequent occurrence after tricuspid valve surgeries, and their management is challenging.

Case Presentation: We present a case of 16-year-old male patient who presented with episodes of presyncope. At the age of 7 years, he underwent tricuspid valve replacement surgery with a biological prosthesis for infective endocarditis sourced from a gluteal abscess.

Establishing a multi-method approach for unprecedented detection and quantification of 13 genotoxic impurities (GTIs) in Apixaban drug substance through ultra-performance liquid chromatography (UPLC).

This groundbreaking study introduces a pioneering development of multi-method approach for the first-ever detection and quantification of 13 genotoxic impurities (GTIs) in Apixaban (Apx) drug substance using ultra-performance liquid chromatography (UPLC) with ultraviolet (UV) detector. In this novel endeavor, two distinct UPLC-UV methods, Method A (for impurities A to G) and Method B (for impurities H to M), were meticulously developed and validated as per International Council for Harmonization (ICH) guidelines to address the challenge of identification and control of 13 GTIs in Apx drug substance. The validation process included rigorous assessment of linearity, accuracy, specificity, precision, limit of quantification (LOQ), and limit of detection (LOD) for each impurity in each method which marks a significant advancement in pharmaceutical analysis.

A Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Manifestation in Tubercular Cervical Lymphadenopathy: A Case Report.

A severe adverse reaction linked to a variety of medications, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is typified by a severe mucocutaneous rash, eosinophilia, fever, lymphadenopathy, and widespread systemic involvement. A 30-year-old female patient presented with fever, facial flushing, and a maculopapular rash that had been persistent for seven days on the upper limb, chest, belly, and lower limbs. She also had a cough with breathlessness for seven days which had progressed over the last seven days and also a rise in temperature in the evening.