Size-Programmable Matteson-Type Annulation: Construction of Spirocycles from Simple Cyclic Ketones.

Despite the recent advancement, Matteson-type reactions are almost exclusively used to construct linear molecules. Herein we report an iterative boron-homologation approach to construct various carbocycles from a single precursor. This method utilizes an electron-withdrawing group (EWG) as a handle to enable intramolecular Matteson-type couplings, leading to diastereoselective and enantioselective ring formation.

A Comparative Analysis of Revision Rates in Surgical Treatments for Lumbar Isthmic Spondylolisthesis.

Study DesignRetrospective Cohort Study.ObjectiveIsthmic spondylolisthesis is frequently encountered in spine surgical practice, though there is a significant variation in surgical management strategies. We sought to evaluate revision rates between patients who underwent anterior-approach lumbar interbody fusion (ALIF) alone, posterolateral fusion (PLF) alone, PLIF/TLIF, and ALIF+PSF.

Cutaneous lupus erythematosus presenting as a nonhealing ulcer in an African American woman: A case report.

Objective: Cutaneous lupus erythematosus (CLE) is a chronic autoimmune disorder of the skin.

Methods: In this report, we describe the case of an African American woman with CLE who had an ulcer on her posterior thigh. Despite this, initial biopsy specimen of the lesion revealed no evidence of CLE until a repeat biopsy 5 months later.