Systematic mapping of nephroureterectomy specimens removed for urothelial cancer: pathological findings and clinical correlations.

The nature and extent of mucosal alterations in 30 consecutive surgical specimens removed for urothelial neoplasia were evaluated by systematic mapping. The findings correlated with pertinent pathological, cytological and clinical data. Generally, the grade of the principal neoplasm paralleled the degree of epithelial disturbance in the grossly normal urothelium, high grade carcinomas being associated consistently with severe changes and low grade cancers with hyperplasia only.

Paratesticular neuroblastoma associated with subependymal giant cell astrocytoma.

We describe a case of neuroblastoma presenting as a paratesticular mass in infancy. To our knowledge this is the first case of a paratesticular neuroblastoma reported in the literature. An operation combined with radiotherapy and chemotherapy has achieved long-term survival despite obvious multifocal disease.

Spindle cell cancer of bladder during cyclophosphamide therapy for Wegener's granulomatosis.

A 38-year-old woman with long-standing Wegener's granulomatosis had remission with cyclophosphamide therapy after failure of response to other agents. Severe cystitis with massive blood loss necessitated a cystectomy. The bladder contained an unsuspected neoplasm, histologically resembling leiomyosarcoma, but desmosomes seen on electron-microscopic examination suggested that this was a spindle cell carcinoma.