Publications by authors named "S B Arumugam"
Background: Systemic inflammation, metabolic dysregulation, and changes in biochemical markers are closely associated with the progression of lung cancer. This study focuses on evaluating serum parathyroid hormone (PTH), C-reactive protein (CRP), lipid profile parameters, and interleukin-6 (IL-6) in relation to the stages of lung cancer, exploring their potential as biomarkers for assessing disease severity.
Methods: A total of 160 lung cancer patients were selected for a cross-sectional study and equally distributed into four clinical stages (Stages 1-4).
Article Synopsis
- Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are commonly used medications for managing diabetes and aiding weight loss but can delay gastric emptying, increasing aspiration risk during surgery.
- Current guidelines suggest pausing these medications before surgery based on expert consensus rather than clear evidence.
- A case series demonstrates how gastric point of care ultrasound (POCUS) assessed gastric contents in three patients, allowing for tailored and safer anesthetic plans based on individual needs and urgency.
Article Synopsis
- - DNA methylation is an important epigenetic mechanism that regulates gene expression, and DNMT inhibitors are used extensively in research to study this process.
- - Researchers developed a CRISPR-based method called SAM-DNMT3A that unexpectedly induces global DNA methylation, regardless of the specific DNA target.
- - This approach reveals a potential therapeutic vulnerability in ER-positive breast cancer and emphasizes the need for careful use of CRISPR technology in methylation studies.
The Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2/Antioxidant Response Elements (Keap1/Nrf2/ARE) pathway is essential for neuronal resilience against the complex pathogenesis of Parkinson's disease (PD). Activating this pathway by covalently modifying Keap1 cysteine residues is a promising strategy for regulating neuroprotective gene expression. Our study aimed to identify phytochemicals that could irreversibly inhibit Keap1.
View Article and Find Full Text PDFNeurofibromatosis (NF) is identified as genetic disorder characterized by multiple tumors on nerve tissues. NF1 is the most prevalent form, identified by neurofibromas and skin changes. NF1 is the most prevalent neurofibromatosis disorder, distinct from the rarer NF2 and schwannomatosis (SWN) conditions.
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