Aims And Background: Glucocorticoids, vitamin C and thiamine have important biological effects in patients with sepsis and septic shock. Multiple studies have demonstrated the beneficial role of a combination therapy of vitamin C, hydrocortisone and thiamine in patients with sepsis and septic shock in terms of mortality reduction, and increase in the number of days free of ventilators and vasopressors.
Materials And Methods: Patients who had septic shock were assessed for eligibility after intensive care unit (ICU) admission.
CD226 plays a vital role in natural killer (NK) cell cytotoxicity, interacting with its ligands CD112 and CD155 to initiate immune synapse formation, primarily through leukocyte function-associated-1 (LFA-1). Our study examined the role of CD226 in NK cell surveillance of acute myeloid leukemia (AML). NK cells in patients with AML had lower expression of CD226.
View Article and Find Full Text PDFThe coronavirus disease 2019 pandemic substantially impacted the delivery of cancer services and programs. Here we reviewed and synthesized the global scale and impact of pandemic-related delays and disruptions on cancer services, including diagnosis, diagnostic procedures, screening, treatment and supportive and palliative care. Based on data from 245 articles in 46 countries, we observed declines in the number of cancer screening participation (39.
View Article and Find Full Text PDFDespite the high prevalence of anemia and malnutrition in Myanmar, the relationship between anemia and body mass index (BMI) remains underexplored. We analyzed nationally representative data from the Myanmar Demographic and Health Survey (MDHS) 2015-2016 to explore the effects of BMI on hemoglobin levels and anemia among children (n = 2,937) and women (n = 9,262). Anemia was defined as hemoglobin levels < 11 g/dl for children and pregnant women, and < 12 g/dl for nonpregnant women, with BMI categories classified according to WHO guidelines.
View Article and Find Full Text PDFAntenatal corticosteroids (ACS) are widely used to reduce respiratory distress syndrome (RDS) in preterm neonates, enhancing neonatal outcomes. However, the potential effects of ACS on other aspects of neonatal health, such as cortisol levels and glucose regulation, remain a concern. This study examines whether ACS administration impacts cortisol and glucose homeostasis in preterm infants by analyzing data from 14 selected studies.
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