Publications by authors named "S B Abramson"
We previously developed human CAR macrophages (CAR-M) and demonstrated redirection of macrophage anti-tumor function leading to tumor control in immunodeficient xenograft models. Here, we develop clinically relevant fully immunocompetent syngeneic models to evaluate the potential for CAR-M to remodel the tumor microenvironment (TME), induce T cell anti-tumor immunity, and sensitize solid tumors to PD1/PDL1 checkpoint inhibition. In vivo, anti-HER2 CAR-M significantly reduce tumor burden, prolong survival, remodel the TME, increase intratumoral T cell and natural killer (NK) cell infiltration, and induce antigen spreading.
View Article and Find Full Text PDFBackground: Atrial fibrillation (AF) is a recognized risk factor for mortality after transcatheter aortic valve replacement for severe aortic stenosis, but the impact of different types of AF on clinical outcomes remains unclear.
Methods: This retrospective study included 982 patients divided into 3 groups: no AF, paroxysmal AF, and nonparoxysmal AF (persistent or permanent). Clinical outcomes were analyzed using inverse probability weighting and multivariate models.
Article Synopsis
- Left bundle branch area pacing (LBBAP) is a new approach to pacing that aims to improve heart function after aortic valve replacement, compared to the traditional right ventricular septal pacing (RVSP).
- The Left Bundle BRAVE study is a clinical trial designed to compare LBBAP and RVSP in patients with severe aortic stenosis and high-degree heart block to see which method better preserves heart function.
- Key outcomes being measured in the study include changes in heart strain and ejection fraction, along with other markers of heart health and patient performance over a 9-month period.