Publications by authors named "S Azab"
Rationale: One of the most debilitating drawbacks of cisplatin chemotherapy is neurotoxicity which elicits memory impairment and cognitive dysfunction (chemobrain). This is primarily triggered by oxidative stress and inflammation. Captopril, an angiotensin-converting enzyme inhibitor, has been reported as a neuroprotective agent owing to its antioxidant and anti-inflammatory effects.
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- The study evaluated quinacrine, an FDA-approved drug, for its protective effects against hepatic encephalopathy (HE) in a rat model with bile duct ligation (BDL) and focused on the liver-brain communication through BMP2 signaling.
- Results indicated that BDL caused significant liver damage and cognitive deficits in rats, but quinacrine treatment improved liver function and cognitive abilities by restoring crucial signaling pathways.
- The findings suggest that quinacrine may offer potential benefits for treating HE by enhancing liver and brain health, highlighting the role of BMP2 signaling in this process.*
Objectives: Long-term exposure to air pollution has been associated with higher risk of cardiovascular mortality. Less is known about the association of air pollution with initial development of cardiovascular disease. Herein, the association between low-level exposure to air pollutants and subclinical carotid atherosclerosis in adults without known clinical cardiovascular disease was investigated.
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- - The study focuses on how decision-making for individuals living with dementia and their care partners can be improved through knowledge translation (KT) interventions, particularly in areas like advance care planning (ACP).
- - Researchers reviewed 22 previous studies and identified 32 different KT interventions, finding that discussions around ACP were the most common focus among them.
- - The analysis revealed that most interventions were geared towards care partners, enhancing their knowledge and confidence, while leading to reduced uncertainty in decision-making for both parties involved.