Effects of glial-derived neurotrophic factor on remodeling and mitochondrial function in human airway smooth muscle cells.

Airway smooth muscle (ASM) cells play important roles in airway remodeling of asthma. Our previous studies show that in vivo administration of glial-derived neurotrophic factor (GDNF) in mice induces thickening and collagen deposition in bronchial airways, whereas chelation of GDNF by GFRα1-Fc attenuates airway remodeling in the context of allergen exposure. To determine whether GDNF has direct effects on ASM, in this study, we examined GDNF in ASM cells from normal versus asthmatic humans.

A Systematic Review on Sociodemographic, Financial and Psychological Factors Associated with COVID-19 Vaccine Booster Hesitancy among Adult Population.

Background: While considerable evidence supports the safety and efficacy of COVID-19 vaccines, a sizable population expresses vaccine hesitancy. As per the World Health Organization, vaccine hesitancy is one of the top 10 hazards to global health. Vaccine hesitancy varies across countries, with India reporting the least vaccine hesitancy.

Relationship between electronic health records strategy and user satisfaction: a longitudinal study using clinicians' online reviews.

Objective: We investigated how the electronic health records (EHRs) strategies concerning EHR sourcing and vendor switching impact user satisfaction over time.

Materials And Methods: This study used a novel longitudinal dataset created by scraping clinicians' Glassdoor.com reviews on 109 US health systems from 2012 to 2017 and combining it with the Healthcare Information and Management Systems Society (HIMSS) database.

A network model of H5N1 avian influenza transmission dynamics in domestic cats.

Naturally occurring cases of influenza in cats owing to the H5N1 strain have been reported in several countries. A cat reservoir of H5N1 in the United States could provide an environment for zoonotic disease spread to humans. This scenario was the impetus to develop a model to study potential transmission of H5N1 virus in domestic cats utilizing information on cat ownership and cat-cat interaction patterns, in addition to biological properties of the virus.

Inertial clustering of particles in high-Reynolds-number turbulence.

We report experimental evidence of spatial clustering of dense particles in homogenous, isotropic turbulence at high Reynolds numbers. The dissipation-scale clustering becomes stronger as the Stokes number increases and is found to exhibit similarity with respect to the droplet Stokes number over a range of experimental conditions (particle diameter and turbulent energy dissipation rate). These findings are in qualitative agreement with recent theoretical and computational studies of inertial particle clustering in turbulence.