Publications by authors named "S Ayabe"
Objective: To evaluate the healing outcome of a platelet-rich plasma (PRP) gel prepared using TKKT01 (a wound care device to prepare the PRP gel) in patients with hard-to-heal diabetic foot ulcers (DFUs) and who showed an inadequate response to ≥4 weeks of standard of care (SoC).
Method: This open-label, single-arm, multicentre study was conducted in 15 centres in Japan. Eligible patients received PRP gel treatment twice a week for eight weeks, followed by a final evaluation after the completion of week 8 (day 57).
Chicory (Cichorium intybus L.; witloof) is a crisp bitter leafy vegetable, popularly used in western cuisine in salads and soups (leaves) and as an alternative to coffee (roasted roots). In this study, we explored the effect of heat processing under various temperatures and for different durations on the nutritional composition of chicory leaves using gas chromatography-mass spectrometry (GC/MS) and principal component analysis (PCA).
View Article and Find Full Text PDFArticle Synopsis
- Genetically engineered mouse models are crucial for studying gene functions and diseases, and genome editing has improved their creation in various mouse strains.
- Zygote electroporation simplifies the process of introducing CRISPR-Cas9, reducing costs and labor involved in this technology.
- The study confirms that this method effectively generates knockout mice in multiple inbred strains, facilitating research in reverse genetics and human disease through successful transmission of targeted mutations.
Article Synopsis
- DExH-box helicases, involved in unwinding RNA and DNA, include genes like DHX30, which is linked to neurodevelopmental disorders; DHX9's variants have not been widely associated with such disorders until now.
- A new report highlights a patient with a de novo missense variant in DHX9 linked to short stature, intellectual disability, and a heart condition, with the variant located in the ATP-binding site.
- Experiments with Drosophila and gene-editing in mice demonstrate that loss-of-function variants in DHX9 can lead to neurodevelopmental issues, supporting its role in these conditions.
Article Synopsis
- - The study presents the first specific reference ranges for electrocardiography (ECG) in laboratory mice, derived from a large dataset of over 26,000 C57BL/6N mice grouped by age and sex.
- - It finds that factors like sex and age have minimal impact on key ECG metrics, while anesthesia significantly reduces heart rate.
- - The reference ranges established for C57BL/6N mice appear applicable to various other mouse strains, providing a crucial resource for research involving cardiac function in experimental settings.