Introduction: Intrahepatic cholestasis of pregnancy (ICP) is one of the most common hepatic disorders during pregnancy, and the etiology is thought to be multifactorial including both environmental and hormonal contributions. In twin pregnancies, the fetal and placental mass is generally greater than in singleton pregnancies, and is, theoretically, likely to have a greater influence upon the maternal hepatic metabolism compared to singleton pregnancy. The aim of this study was to compare ICP in twin and singleton pregnancies according to ICP characteristics, time of diagnosis, serum bile acid levels, pharmacological treatment, and pregnancy outcomes.
View Article and Find Full Text PDFObjective: To investigate how reproductive history was associated with urinary incontinence in midlife.
Design: A follow-up study.
Setting: Denmark.
(1) Background: The role of cytoreductive nephrectomy (CN) is controversial in patients with primary metastatic renal cell carcinoma (mRCC). (2) Methods: We evaluated the impact of CN, or no CN, followed by first-line targeted therapy (TT) in a nationwide unselected cohort of 437 consecutive patients with primary mRCC over a two-year period with a minimum of five years of follow-up. Data sources were national registries supplemented with manually extracted information from individual patient medical records.
View Article and Find Full Text PDFIntroduction And Hypothesis: The objective was to investigate how weight change across and after the childbearing years was associated with urinary incontinence (UI) in midlife.
Methods: Data were obtained from 35,645 women responding to the Maternal Follow-up questionnaire in the Danish National Birth Cohort in 2013-2014. Outcome was self-reported UI and its subtypes.
Introduction: The purpose of this study was to explore if and how urinary incontinence affects work capacity and work-related quality of life.
Methods: This was a cross-sectional questionnaire study using a Danish validated questionnaire. The questionnaire was distributed to Danish municipal employees.