Prioritizing Parkinson's disease risk genes in genome-wide association loci.

Recent advancements in Parkinson's disease (PD) drug development have been significantly driven by genetic research. Importantly, drugs supported by genetic evidence are more likely to be approved. While genome-wide association studies (GWAS) are a powerful tool to nominate genomic regions associated with certain traits or diseases, pinpointing the causal biologically relevant gene is often challenging.

Comparing the efficacy of oral apremilast, intralesional corticosteroids, and their combination in patients with patchy alopecia areata: a randomized clinical controlled trial.

Introduction: Alopecia areata (AA) is a chronic, immune-mediated inflammatory disorder characterized by nonscarring hair loss. The management of AA poses challenges due to its unpredictable course and variable response to treatment. In this comparative study, we evaluated the efficacy and safety of oral apremilast, intralesional corticosteroids (ILC) and a combination of both in patients with patchy AA.

Recent advances in platelet-rich plasma and its derivatives: therapeutic agents for tissue engineering and regenerative medicine.

Platelet rich plasma (PRP) is a suspension of bioactive factors and chemokine enriched plasma. Platelets are a distinctive source of membrane bound and soluble proteins that are released upon their activation. The higher count of platelets renders PRP with an array of tissue regenerative abilities.

Tough, durable and strongly bonded self-healing cartilage-mimicking noncovalently assembled hydrogel nanostructures: the interplay between experiment and theory.

High-strength, strongly bonded and self-healing materials are of great interest for several applications; however, the experimental and design of all such properties in a single material is challenging. In the present work, inspired by cartilage tissue, polyacrylamide (PAM)-based tough and durable dimer (PAM-Ag and PAM-BNOH) and trimer (PAM-Ag-BNOH) nanocomposites were synthesized by encapsulating silver (Ag) and hydroxylated hexagonal boron nitride (BNOH). Strong interfacial interaction was achieved by introducing (computational modelling and DFT approaches) noncovalent bonds in the dimer and trimer nanohybrids.

Assessment of knowledge and behavioral risk factors of reproductive tract infections among married women of 15-49 years in rural areas of Haldwani block, Uttarakhand.

Background: One of the most serious public health issues in India is reproductive tract infections (RTIs), which have a profound effect on the lives of men and women, as well as their families and communities.

Objectives: To describe the sociodemographic traits, assess women's RTI knowledge, and determine which behavioral risk factors are involved in female RTI.

Methods: Using a 30-cluster sampling approach, a cross-sectional study design was employed to examine RTIs in 30 villages located in the Haldwani block of the district Nainital.