Publications by authors named "S Avenarius"
Background: Randomized controlled trials have indicated reduced mortality rates in very preterm infants assigned to high compared to low oxygen saturation (SpO) target levels, accompanied by higher rates of retinopathy of prematurity and bronchopulmonary dysplasia. However, the benefit-to-harm ratio may depend on the local background mortality risk. We therefore aimed to quantify the risk-benefit ratios of different SpO target ranges in 10 tertiary newborn intensive care units (NICUs) in East Germany.
View Article and Find Full Text PDFImportance: Red blood cell transfusions are commonly administered to infants weighing less than 1000 g at birth. Evidence-based transfusion thresholds have not been established. Previous studies have suggested higher rates of cognitive impairment with restrictive transfusion thresholds.
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- The study investigates how the partial pressure of CO2 (PCO2) impacts health outcomes for extremely low birth weight infants, specifically looking at different classifications of PCO2 levels: hypocapnia, normocapnia, hypercapnia, and fluctuating PCO2.
- Results showed that infants in the hypercapnic group had higher mortality rates and higher occurrences of complications such as bronchopulmonary dysplasia (BPD) and necrotizing enterocolitis (NEC), and these outcomes were linked to higher mean airway pressure (MAP) combined with oxygen levels (FiO2).
- The analysis concluded that both birth weight and respiratory status (as indicated by MAP × Fi
Article Synopsis
- The study assessed the neurodevelopmental outcomes of extremely low birthweight infants subjected to different partial pressures of carbon dioxide (PCO) during mechanical ventilation.
- There were no significant differences in growth metrics or developmental indices (MDI and PDI) between infants receiving high PCO and those with mildly elevated targets.
- High PCO targets were deemed safe, suggesting that optimizing short-term ventilation strategies does not adversely affect long-term neurodevelopment.
Background: Tolerating higher partial pressure of carbon dioxide (pCO2) in mechanically ventilated, extremely low birthweight infants might reduce ventilator-induced lung injury and bronchopulmonary dysplasia. We aimed to test the hypothesis that higher target ranges for pCO2 decrease the rate of bronchopulmonary dysplasia or death.
Methods: In this randomised multicentre trial, we recruited infants from 16 tertiary care perinatal centres in Germany with birthweight between 400 g and 1000 g and gestational age 23-28 weeks plus 6 days, who needed endotracheal intubation and mechanical ventilation within 24 h of birth.