Publications by authors named "S Avasarala"
Article Synopsis
- The FDA approved capivasertib in combination with fulvestrant for adult patients with hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer who have certain genetic alterations and have previously undergone endocrine therapy.
- The approval came from the CAPItello-291 trial, which involved 708 patients, showing that capivasertib significantly improved progression-free survival, particularly in patients with specific tumor alterations.
- While capivasertib showed benefits, it also led to higher rates of severe side effects like hyperglycemia, skin issues, and diarrhea in some patients.
. Temporal patterns in neuronal spiking encode stimulus uncertainty, and convey information about high-level functions such as memory and cognition. Estimating the associated information content and understanding how that evolves with time assume significance in the investigation of neuronal coding mechanisms and abnormal signaling.
View Article and Find Full Text PDFBackground: Prior studies have found no differences in procedural chest discomfort for patients undergoing manual syringe aspiration or drainage with gravity after thoracentesis. However, whether gravity drainage could protect against chest pain due to the larger negative-pressure gradient generated by wall suction has not been investigated.
Research Question: Does wall suction drainage result in more chest discomfort compared with gravity drainage in patients undergoing large-volume thoracentesis?
Study Design And Methods: In this multicenter, single-blinded, randomized controlled trial, patients with large free-flowing effusions of ≥ 500 mL were assigned at a 1:1 ratio to wall suction or gravity drainage.
Background: Robotic-assisted bronchoscopy has recently emerged as an alternative to electromagnetic navigational bronchoscopy for the evaluation of peripheral pulmonary lesions. While robotic-assisted bronchoscopy is proposed to have several advantages, such as an easier learning curve, it is unclear if it has comparable diagnostic utility as electromagnetic navigational bronchoscopy.
Methods: Robotic versus Electromagnetic bronchoscopy for pulmonary LesIon AssessmeNT (RELIANT) is an investigator-initiated, single-center, open label, noninferiority, cluster randomized controlled trial conducted in two operating rooms at Vanderbilt University Medical Center.