Publications by authors named "S Atalay Vural"
Immunocytochemistry of myoepithelial cell types in canine mammary tumors.
Biotech Histochem
December 2024
Myoepithelial cells (MECs) are known to play an active role in mixed mammary tumors and are found in dogs as well as in humans. The study aimed to assess the morphologic features of epithelial and mesenchymal cells and MECs and investigate their roles in epithelial-mesenchymal transformation in different tumor types in canine mammary tumors. Immunohistochemical staining was performed on 165 specimens from benign mixed tumors (BMT), carcinosarcomas, and simple carcinomas (SC).
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- Single-cell RNA sequencing (scRNAseq) and flow cytometry in skin research are expensive and complex, often limiting their use for researchers, particularly when analyzing both RNA and protein from the same samples.* -
- The study introduces a new sample multiplexing strategy that allows for simultaneous scRNAseq and flow cytometry on paired blood and skin samples, enhancing data collection and analysis across healthy and inflamed specimens.* -
- This novel approach not only cuts costs by 2-4 times and reduces technical issues but also includes detailed protocols for implementation, making advanced skin analysis techniques more accessible for researchers.*
Article Synopsis
- Pyometra is a serious inflammatory disease affecting older intact female dogs, particularly during the diestrus stage, and can lead to significant health issues.
- The study examined five types of aquaporins (proteins that help transport water) in uterine tissue and their links to various health markers like blood lipopolysaccharide levels and antioxidant activity in dogs with pyometra.
- Results showed changes in aquaporin levels between affected dogs and control dogs, including downregulation of AQP1, AQP2, and AQP5, while AQP9 and AQP3 were upregulated, suggesting a complex relationship between these proteins and the disease's progression.