Dynamic transcription factor activity and networks during ErbB2 breast oncogenesis and targeted therapy.

Tissue development and disease progression are multi-stage processes controlled by an evolving set of key regulatory factors, and identifying these factors necessitates a dynamic analysis spanning relevant time scales. Current omics approaches depend on incomplete biological databases to identify critical cellular processes. Herein, we present TRACER (TRanscriptional Activity CEll aRrays), which was employed to quantify the dynamic activity of numerous transcription factor (TFs) simultaneously in 3D and networks for TRACER (NTRACER), a computational algorithm that allows for cellular rewiring to establish dynamic regulatory networks based on activity of TF reporter constructs.

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.

Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. It is also expressed in normal epithelial linings of the gastrointestinal tract, skin, and prostate. To date, expression of PTK6 has not been extensively examined in the normal human mammary gland.

Search for hidden sector photons with the ADMX detector.

Hidden U(1) gauge symmetries are common to many extensions of the standard model proposed to explain dark matter. The hidden gauge vector bosons of such extensions may mix kinetically with standard model photons, providing a means for electromagnetic power to pass through conducting barriers. The axion dark matter experiment detector was used to search for hidden vector bosons originating in an emitter cavity driven with microwave power.

Search for chameleon scalar fields with the axion dark matter experiment.

Scalar fields with a "chameleon" property, in which the effective particle mass is a function of its local environment, are common to many theories beyond the standard model and could be responsible for dark energy. If these fields couple weakly to the photon, they could be detectable through the afterglow effect of photon-chameleon-photon transitions. The ADMX experiment was used in the first chameleon search with a microwave cavity to set a new limit on scalar chameleon-photon coupling βγ excluding values between 2×10(9) and 5×10(14) for effective chameleon masses between 1.