A new framework on climate-induced food-security risk for small-scale fishing communities in Tanzania.

Unlabelled: Food insecurity is a pressing issue facing our world, particularly affecting coastal communities who rely on marine resources. The problem is further compounded by the rapidly changing climate, a deteriorating environment and growing human populations. It is essential to evaluate this issue accurately to reduce risk and improve the situation of coastal communities, especially in countries with less socioeconomic development.

Chrysin downregulates the expression of ADAMTS-4 in foam cells.

Background: Chrysin, a polyphenolic compound, possesses antioxidant and anti-inflammatory properties. In this study, we investigated the effect of chrysin on the expression of A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), a protease enzyme involved in degrading extracellular matrix associated with atherosclerosis.

Methods And Results: We have studied the cell viability by MTT assay and foam cell formation by oil red O staining.

Sesame oil downregulates the expression of ADAMTS-4 in high-fat diet-induced atherosclerosis.

Atherosclerosis is a chronic inflammatory disease forming plaques in medium and large-sized arteries. ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs-4) is an extracellular-matrix remodelling enzyme involved in the degradation of versican in the arterial wall. Recent reports indicated that increased expression of ADAMTS-4 is associated with plaque progression and vulnerability.

Oxidized LDL-mediated upregulation of ADAMTS-4 in monocytes/macrophages involves ROS-NF-κB-SIRT-1 pathway.

Background And Aims: ADAMTS-4 is a protease enzyme involved in vascular remodeling and atherosclerosis. It was found to be upregulated in macrophages seen in atherosclerotic lesions. This study aimed to investigate the expression and regulation of ADAMTS-4 in oxidized LDL-induced human monocytes/macrophages system.