Publications by authors named "S Aslibekyan"
Article Synopsis
- * A study of 445 PD patients revealed a higher diversity of microbes compared to 221 controls, with specific bacterial overabundances and depletions identified as key signatures of PD.
- * Findings indicate that certain oral microbiome characteristics could act as potential biomarkers for early PD detection, particularly in relation to non-motor symptoms linked to the peripheral nervous system.
Article Synopsis
- The LRRK2 G2019S variant is the leading cause of hereditary Parkinson's disease, studied in a large cohort of carriers and controls over 3.5 years, revealing significant insights into disease progression and symptoms.
- G2019S carriers face a 49% chance of developing PD by age 80, with a 10-fold increased risk compared to non-carriers, and an even higher risk for those with elevated polygenic risk scores.
- The research highlights that G2019S-associated PD is a slower-progressing form, primarily affecting motor functions while showing fewer non-motor symptoms, suggesting a need to adjust current diagnostic criteria for earlier detection.
Article Synopsis
- Genome-wide association studies (GWAS) have successfully identified genes linked to telomere length, but previous research hadn't validated these findings until now.
- In a large analysis involving over 211,000 people, the study discovered five new signals linked to telomere length and highlighted the importance of blood/immune cells in this area.
- The researchers confirmed that the genes KBTBD6 and POP5 truly affect telomere length by demonstrating that manipulating these genes can lengthen telomeres and that their regulation is crucial for understanding telomere biology.
Objective: Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology. Multiple genetic and environmental factors have been associated with PD, but most PD risk remains unexplained. The aim of this study was to test for statistical interactions between PD-related genetic and environmental exposures in the 23andMe, Inc.
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- Educational attainment is linked to cardiovascular health, and a large genomic study examined how it interacts with cholesterol and triglyceride levels in nearly 226,315 individuals across five population groups.
- The study identified 18 new genetic variations related to lipid levels—nine for low-density lipoprotein (LDL), seven for high-density lipoprotein (HDL), and two for triglycerides (TG)—some of which interact with educational attainment.
- Researchers also found five gene targets that potentially interact with FDA-approved drugs, suggesting a connection between genetics and drug responses related to lipid metabolism and overall health.