Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats.

The anterior cingulate cortex is responsible for multiple cognitive functions like fear, pain management, decision-making, risk and reward assessment, and memory consolidation. However, its cell-type-specific functions are not clearly understood. To reveal the selective functional role of Parvalbumin-expressing GABAergic interneurons in the ACC, we knocked down (KD) the PV gene in-vivo in rats.

Redefining the Reference Interval and Cut-Off Values of the Hematological and Biochemical Parameters and Deriving a Sensitive Predictive Marker for Crisis Events in Sickle Cell Disease.

Unlabelled: The heterogeneity in clinical presentations in sickle cell disease (SCD) alters between crisis and steady state phases. Considering the pathophysiology, it is crucial to establish a disease-specific reference interval for hematological and biochemical parameters and identify the sensitive predictive markers for crisis. The case-control study included fifty-four healthy control, forty SCD cases in crisis state, and forty-six steady state cases.

Knowledge, Attitudes, and Practices (KAP) of Postgraduate Medical Trainees Regarding Patient Care in Diabetes and Hypertension.

Background: Diabetes and hypertension are common chronic illnesses that need to be effectively managed. To improve patient outcomes, healthcare workers' knowledge, attitudes, and practices (KAP) are essential.

Objective: This study aimed to evaluate the KAP of postgraduate medical trainees regarding the management of diabetes and hypertension.

SyncGenie: A programmable event synchronization device for neuroscience research.

In neuroscience, accurately correlating brain activity with stimuli and other events requires precise synchronization between neural data and event timing. To achieve this, purpose-built synchronization devices are often used to detect events. This paper introduces SyncGenie, a programmable synchronization device designed for a range of uses in neuroscience research-primarily as a "trigger box" to align neurophysiological data with physical stimulus events, among other possibilities.

Efficacy and safety of ivermectin-albendazole combination versus ivermectin or albendazole monotherapy in soil-transmitted helminthiasis: A systematic review and meta-analysis.

Background: Soil-transmitted helminthiasis remains a daunting challenge to global health, exerting its greatest toll on resource-limited regions of the world. A dual drug approach using the co-administration of ivermectin and albendazole has shown promising results in comparison to the traditional monotherapy strategy. In light of this, a systematic review and meta-analysis of randomized controlled trials was conducted.