Publications by authors named "S Ashley McCullough"

Wildfires adversely impact air quality and public health worldwide. Exposures to wildfire smoke are linked to adverse health outcomes, including cardiopulmonary diseases. Critical research gaps remain surrounding the underlying biological pathways leading to wildfire-induced health effects.

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Purpose: The Predicting Myopia Onset and progression (PreMO) risk indicator, developed using data generated from white children in the UK, incorporates age, spherical equivalent refraction (SER), axial length (AL) and parental myopia to stratify the likelihood of developing myopia. This study evaluated the PreMO's predictive accuracy using prospective datasets from independent samples of children in Hong Kong (HK) and an ethnically diverse cohort of children in the United Kingdom.

Methods: Non-myopic children (SER > -0.

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The use of new approach methodologies (NAMs) to assess respiratory irritation depends on several factors, including the specifics of exposure methods and cell/tissue-based test systems. This topic was examined in the context of human health risk assessment for cleaning products at a 1-day public workshop held on 2 March 2023, organized by the American Cleaning Institute (ACI). The goals of this workshop were to (1) review NAMs for evaluation of respiratory irritation, (2) examine different perspectives on current challenges and suggested solutions, and (3) publish a manuscript of the proceedings.

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Aim: To determine the regional and ethnic differences in ocular axial elongation and refractive error progression in myopic and non-myopic children.

Methods: A retrospective analysis of 15 longitudinal clinical and population-based studies was conducted in the UK, Sweden, Australia (classified as European), China, and Vietnam (classified as East Asian) between 2005 and 2021. A total of 14,593 data points from 6208 participants aged 6-16 years with spherical equivalent from +6 to -6 D were analysed.

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Article Synopsis
  • Standard information reporting is essential for consistent assay conditions and data, enabling easier comparisons between laboratories.
  • The publication presents the Minimum Information for Reporting on the TEER assay (MIRTA), a key method used to assess cell culture models and toxicity potential.
  • Developed through an international collaboration, the recommendations from the RespTox Collaborative aim to improve data transparency, reproducibility, and quality in both respiratory and other cell systems.
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