Suprascapular nerve entrapment caused by intraosseous cystic lesions is a rare condition. We present the case of a 49-year-old man with right shoulder numbness, slight infraspinatus (ISP) weakness, and shoulder pain. He underwent open surgery and arthroscopic evaluation.
View Article and Find Full Text PDFThe opioid system plays crucial roles in modulating social behaviors in both humans and animals. However, the pharmacological profiles of opioids regarding social behavior and their therapeutic potential remain unclear. Multiple pharmacological, behavioral, and immunohistological c-Fos mapping approaches were used to characterize the effects of μ-opioid receptor agonists on social behavior and investigate the mechanisms in naive mice and autism spectrum disorder-like (ASD-like) mouse models, such as prenatally valproic acid-treated mice and Fmr1-KO mice.
View Article and Find Full Text PDFEndovascular aneurysm repair (EVAR) is commonly utilized for iliac artery aneurysms (IAA), yet some cases necessitate additional intervention due to aneurysm re-expansion. We report two cases: a 68-year-old male with a left internal IAA (IIAA) and an 80-year-old female with both a left common iliac artery aneurysm (CIAA) and IIAA, who underwent aneurysmorrhaphy following initial EVAR. Both procedures were successful, significantly reducing aneurysm size without immediate complications.
View Article and Find Full Text PDFRenal secretion plays an important role in excretion of drug from the kidney. Two major transporters known to be highly involved in renal secretion are MATE1/2 K and OCT2, the former of which is highly related to drug-drug interactions. Among published in silico models for MATE inhibitors, a previous model obtained a ROC-AUC value of 0.
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