Experimental Induction of Anti-Muscarinic Type-3-Receptor Extracellular Loop Antibodies by Immunization with 4-Hydroxy-2-nonenal Modified Ro60 and Unmodified Ro60.

Objective: Sjögren's Disease (SjD) subjects have decreased lacrimal/salivary gland function. Studies have proposed that autoantibodies targeting G-protein-coupled muscarinic acetylcholine-type-3-receptor (M3R) are potential clinical markers for SjD. We hypothesized that rabbits/mice immunized with 4-hydroxy-2-nonenal (HNE)-modified/unmodified Ro60 will develop an autoimmunity, specifically a SjD phenotype, thus expressing increased levels of anti-M3R antibodies.

Primary Pulmonary Choriocarcinoma With Lymph Node Metastasis: A Case Report and Brief Review.

Choriocarcinoma is a malignant germ cell tumor containing syncytiotrophoblasts and secreting human chorionic gonadotropin (β-hCG), often associated with a poor prognosis. Reports of primary choriocarcinoma of the lung with lymph node metastasis are extremely rare in the literature. Here, we report a surgically treated case of primary pulmonary choriocarcinoma in a 32-year-old woman.

gen. nov. sp. nov., a novel aerobic anoxygenic phototrophic bacteria isolated from reef-building coral.

The photosynthetic microorganisms within the coral holobiont produce energy and organic compounds through photosynthesis, which are vital for the biocalcification and heat tolerance of coral hosts. However, aerobic anoxygenic phototrophic bacteria (AAPB), which are one of the most important photosynthetic microorganisms, have not been thoroughly investigated in this environment. In this study, a novel AAPB, SCSIO 66989, was isolated from the reef-building coral sp.

Lot quality assurance sampling for coverage evaluation of a new vaccine: A pilot study.

Background: Worldwide, vaccine-preventable diseases have been a significant cause of mortality in the under-5 age group. To reduce the disease burden, new vaccines are being introduced in every country's immunization programmes. For this to happen, high vaccination coverage is necessary.