Publications by authors named "S Ariotti"
Article Synopsis
- Venomous snake bites, like those from the Vipera aspis, can lead to serious medical emergencies, including rare cardiovascular issues, and require immediate treatment.
- A case study of a 33-year-old reptile zoo keeper shows severe complications after a viper bite, including angioedema, severe thrombocytopenia, anemia, and compartment syndrome, necessitating surgical intervention and supportive transfusions.
- The patient also experienced cardiac issues such as low blood pressure and myocarditis, confirmed by echocardiography and MRI, highlighting the need for early identification and treatment of uncommon complications from snake bites with antivenom.
Article Synopsis
- Immunological memory is essential for immune defense, especially in areas prone to infections, like epithelial sites.
- CD8 memory T cells are formed during infections and can develop into tissue-resident memory cells, primarily in response to type-1 infections, while type-1 regulatory T cells play a crucial role in this process.
- Research with three lung infection models revealed that type-2 helminth infections do not generate CD8 T cells, unlike type-1 and type-3 infections, suggesting that the latter rely on specific immune responses and could influence vaccine design targeting CD8 T cells.
Unexpected Pulmonary Embolism Late After Recovery from Mild COVID-19?
Eur J Case Rep Intern Med
December 2021
Unlabelled: SARS-CoV-2 infection is associated with an increased risk of venous thromboembolism (VTE), which is common during active illness but unusual in milder cases and after healing. We describe a case of bilateral acute pulmonary embolism occurring 3 months after recovery from a paucisymptomatic SARS-CoV-2 infection. The only VTE risk factor demonstrable was a history of previous SARS-CoV-2 infection, with laboratory signs of residual low-grade inflammation.
View Article and Find Full Text PDFExperience with angiotensin-receptor neprilysin inhibitors (ARNI) in oncologic patients with heart failure (HF) is limited. We report a case of ARNI started as first-choice therapy in a patient with relapsing hairy cell leukaemia (HCL) and HF with depressed left ventricular ejection fraction (LVEF). A middle-aged male, previously treated with rituximab for HCL, was scheduled for cardiologic screening before starting a new antineoplastic therapy for cancer relapse.
View Article and Find Full Text PDFFunctional tuning of T cells based on their degree of self-reactivity is established during positive selection in the thymus, although how positive selection differs for thymocytes with relatively low versus high self-reactivity is unclear. In addition, preselection thymocytes are highly sensitive to low-affinity ligands, but the mechanism underlying their enhanced T cell receptor (TCR) sensitivity is not fully understood. Here we show that murine thymocytes with low self-reactivity experience briefer TCR signals and complete positive selection more slowly than those with high self-reactivity.
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