Assessment of CRISPRa-mediated overexpression in an Parkinson's disease model.

Introduction: Parkinson's disease (PD) presents a significant challenge in medical science, as current treatments are limited to symptom management and often carry significant side effects. Our study introduces an innovative approach to evaluate the effects of overexpression mediated by CRISPRa in an model of Parkinson's disease. The expression of can have neuroprotective effects, being related to the modulation of neuroinflammation and pathways associated with cell survival, differentiation, and growth.

Sodium lignosulfonate as an extracting agent of methylene blue dye using a polymer-enhanced ultrafiltration technique.

The purpose of this research was to evaluate the efficacy of sodium lignosulfonate (LS) as a dye adsorbent in the removal of methylene blue (MB) from water by polymer-enhanced ultrafiltration. Various parameters were evaluated, such as membrane molecular weight cut-off, pH, LS dose, MB concentration, applied pressure, and the effect of interfering ions. The results showed that the use of LS generated a significant increase in MB removal, reaching an elimination of up to 98.

Pain assessment and management among adult patients in a gynecology ward: a best practice implementation project.

Objectives: This project aimed to improve compliance with evidence-based practice in pain assessment and management in a gynecology ward.

Introduction: Effective pain control is important to prevent the negative consequences of pain that is poorly managed. However, it remains undervalued and inadequately treated.

Prevalence of Gastric Preneoplastic Lesions in First-Degree Relatives of Patients with Gastric Cancer: a Cross-Sectional Study.

Purpose: Worldwide, gastric cancer (GC) is the 5 cancer with the highest incidence and the 4 in mortality. To reduce it, one strategy is to diagnose preneoplastic lesions (PNL): atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia (DYS); to form risk groups on which to focus surveillance efforts as are first-degree relatives (FDR). The aim of this study was to determine prevalence of gastric PNL in FDR of patients with GC, and to study association with sex, age, and Helicobacter pylorii (Hp) infection.

Removal of Dyes by Polymer-Enhanced Ultrafiltration: An Overview.

The current problem of contamination caused by colored industrial effluents has led to the development of different techniques to remove these species from water. One of them, polymer-enhanced ultrafiltration (PEUF), has been systematically studied in this mini review, in which research works from 1971 to date were found and analyzed. Dye retention rates of up to 99% were obtained in several cases.