Publications by authors named "S Arakelov"
Background: Despite the success of first-generation COVID-19 vaccines targeting the spike (S) protein, emerging SARS-CoV-2 variants have led to immune escape, reducing the efficacy of these vaccines. Additionally, some individuals are unable to mount an effective immune response to S protein-based vaccines. This has created a need for alternative vaccine strategies that are less susceptible to mutations and capable of providing broad and durable protection.
View Article and Find Full Text PDFWe have developed Convacell-a COVID-19 vaccine based on the recombinant nucleocapsid (N) protein of SARS-CoV-2. This paper details Convacell's combined phase I/II and IIb randomized, double-blind, interventional clinical trials. The primary endpoints were the frequency of adverse effects (AEs) and the titers of specific anti-N IgGs induced by the vaccination; secondary endpoints included the nature of the immune response.
View Article and Find Full Text PDFThe development of liquid energetic fuels with improved properties is an important topic in space propulsion technologies. In this manuscript, a series of energetic ionic liquids incorporating a 1,2,5-oxadiazole ring and nitrate, dicyanamide or dinitramide anion was synthesized and their physicochemical properties were evaluated. The synthesized compounds were fully characterized and were found to have good thermal stabilities (up to 219 °C) and experimental densities (1.
View Article and Find Full Text PDFArticle Synopsis
- * The vaccine was tested on various animals, including mice, rabbits, and marmoset monkeys, and showed safety and strong immune responses, including N-specific IgG and T cell responses.
- * In infected Syrian hamsters, the vaccine reduced lung damage and virus levels, demonstrating its effectiveness and potential to complement current COVID-19 vaccines.
[THE RESULTS OF THE ANALYSIS OF RISK FACTORS, CARDIOVASCULAR RISK, CHRONIC NON-COMMUNICABLE DISEASES IN YOUNG AND MIDDLE-AGED PATIENTS, DEPENDING ON THE EDUCATION].
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
December 2022
Aim: To assess the frequency of risk factors (RF), total cardiovascular risk (CHR) and their association with the level of education in young and middle-aged people.
Methods: Persons aged 25-59 (40.4 ± 9.