Publications by authors named "S Aosasa"
Article Synopsis
- The study investigates the effectiveness of conversion surgery in patients with initially unresectable advanced pancreatic ductal adenocarcinoma (PDAC) by analyzing surgical resection rates and survival outcomes from 2013 to 2018.
- In a sample of 211 patients classified as resectable (R), borderline resectable (BR), and unresectable (UR), resection rates were highest in the R group (99%) and lowest in the UR group (19%), with overall survival markedly differing across groups (31 months for R, 18 months for BR, and 11 months for UR).
- Patients who underwent surgical resection showed similar relapse-free and overall survival rates regardless of their initial classification, suggesting that while conversion surgery is
Introduction: Growing evidence indicates the prognostic importance of the crosstalk between cancer cells and stroma through the induction of epithelial-mesenchymal transition (EMT). This study aimed to clarify the prognostic value of evaluating primary tumor histology with the anatomical extent of disease in patients with colorectal liver metastasis (CRLM).
Methods: Prognostic analyses were performed in 411 CRLM patients who underwent hepatectomy at two institutions.
Prognostic significance of regional lymph node metastasis according to station in ampullary carcinoma.
J Hepatobiliary Pancreat Sci
October 2020
Background: The TNM (Tumor, Node, Metastasis) classification of the 8th Union for International Cancer Control and the 6th Japanese classification of biliary tract cancer were made on the premise that the prognostic effect of each regional lymph node station is similar. However, some studies have reported different effects of lymph node metastasis location on post-resection prognosis. This study aimed to investigate outcome following radical resection of ampullary carcinoma according to station of lymph node metastasis.
View Article and Find Full Text PDFBackground: Many patients undergoing hepatectomy for colorectal liver metastases (CRLM) experience recurrence. However, no criteria for screening candidates to undergo repeat hepatectomy (RH) for CRLM have been established. Budding, one form by which colorectal carcinoma malignancies are expressed, is a new pathologic index.
View Article and Find Full Text PDFArticle Synopsis
- The Japanese guidelines recommend everolimus or sunitinib as first-line treatments for unresectable pancreatic neuroendocrine tumors (PNETs), with streptozocin (STZ) as an alternative.
- A 50-year-old patient with PNET and multiple liver metastases showed a significant response to third-line treatment with STZ after failing to respond to everolimus and sunitinib.
- The situation highlights the need for further research to identify the optimal order of anti-cancer drugs and their effectiveness for treating PNET, as treatment responses can vary significantly.