SOX4 induces cytoskeleton remodeling and promotes cell motility via N-wasp/ARP2/3 pathway in colorectal cancer cells.

Filopodia are thin, actin-rich projection from the plasma membrane that promote cancer cell invasion and migration. Sex-determining region Y-related high-mobility group-box 4 (SOX4) is a crucial transcription factor that plays a role in the development and metastasis of colorectal cancer (CRC). However, the involvement of SOX4 in cytoskeleton remodeling in CRC remains unknown.

SOX4/HDAC2 Axis Enhances Cell Survivability and Reduces Apoptosis by Activating AKT/MAPK Signaling in Colorectal Cancer.

Background: Increased SOX4 (SRY-related HMG-box) activity aids cellular transformation and metastasis. However, its specific functions and downstream targets remain to be completely elusive in colorectal cancer (CRC).

Aims: To investigate the role of SOX4 in CRC progression and the underlying mechanism.

Clonal evolution and expansion associated with therapy resistance and relapse of colorectal cancer.

Colorectal cancer (CRC) arises by a continuous process of genetic diversification and clonal evolution. Multiple genes and pathways have a role in tumor initiation and progression. The gradual accumulation of genetic and epigenetic processes leads to the establishment of adenoma and cancer.

Antiproliferative and apoptotic potential of methotrexate lipid nanoparticles in a murine breast cancer model.

To evaluate the efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) and in the treatment of breast cancer. MTX-NPs were tested for cellular uptake, cell viability, cell cycle, cellular wound migration and changes in tumor volume using characterized NPs. The solid lipid NPs (SLNPs) showed strong cellular uptake, increased apoptosis, controlled cytotoxicity at lower IC of methotrexate and a sizable reduction in tumor burden.

Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Leaf Extract on Colorectal Cancer Cells.

Chemotherapy side effects, medication resistance, and tumor metastasis impede the advancement of cancer treatments, resulting in a poor prognosis for cancer patients. In the last decade, nanoparticles (NPs) have emerged as a promising drug delivery system. has long been used as a treatment option to treat a variety of ailments.