Publications by authors named "S Antoniu"
In the clinical context of stroke, health-related quality of life (HRQOL) is a crucial patient-reported outcome measure that is frequently used to assess the effectiveness of neurorehabilitation programs. Despite its significance, the absence of a stroke-specific quality-of-life instrument translated into Romanian and validated for use in Romanian stroke patients, including those with aphasia, presents a notable gap in current research. This study briefly describes the translation and cross-cultural adaptation of the Stroke and Aphasia Quality of Life Scale-39 g (SAQOL-39 g) into Romanian (RO-SAQOL-39 g).
View Article and Find Full Text PDFProtein phosphatase 2A activators under investigation for smoking-related chronic obstructive pulmonary disease and related disorders.
Expert Opin Investig Drugs
November 2024
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) and other chronic respiratory disorders like cystic fibrosis and alpha-one antitrypsin deficiency share inflammation and progression characteristics, prompting investigations into anti-inflammatory treatments.
- A systematic review of studies from 2000 onward focuses on the role of protein phosphatase 2A (PP2A) in inflammation, its suppression by smoking, and the potential benefits of its activation in treating COPD.
- Experts suggest that activating PP2A could be a viable therapy for COPD and related disorders, highlighting promising avenues like repurposing metformin and inhalation methods, although most evidence is still in the experimental stage.
With a constant increase in prevalence and incidence worldwide, stroke remains a public health issue in the 21 century. Additionally, population aging inevitably leads to increased vulnerability in the general population, a clinical state known as frailty. While there are adequate guidelines on the treatment of stroke in the acute setting, there are a lot of gaps regarding the chronic management of stroke patients, particularly the frail ones.
View Article and Find Full Text PDFIntroduction: Non-small cell lung cancer (NSCLC) is a disease commonly diagnosed in the elderly, often in advanced stages. However, elderly patients with lung cancer can benefit from surgery, provided that postoperative risks are assessed appropriately before surgery. Frailty is a measure of age-related impaired functional status and a predictor of mortality and morbidity.
View Article and Find Full Text PDFNavafenterol for chronic obstructive pulmonary disease therapy.
Expert Opin Investig Drugs
April 2023
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) is a common airway disease, and inhaled bronchodilators, like navafenterol, are being explored as effective treatment options to manage symptoms and improve patients' quality of life.
- Navafenterol works as a bifunctional bronchodilator, showing promising results in preclinical and clinical studies by enhancing lung function and reducing symptoms like dyspnea and cough in moderate-to-severe COPD patients.
- Although the evidence for navafenterol's effectiveness is still developing, it indicates the need for more clinical research and potential exploration of combinations with other treatments, particularly with other bifunctional molecules.