Publications by authors named "S Antoku"
Unlabelled: The recycling of integrin endocytosed during focal adhesion (FA) disassembly is critical for cell migration and contributes to the polarized formation of new FAs toward the leading edge. How this occurs is unclear. Here, we sought to identify the kinesin motor protein(s) that is involved in recycling endocytosed integrin back to the plasma membrane.
View Article and Find Full Text PDFObjective To determine the clinical background factors of patients with type 2 diabetes who showed deterioration of defecation status after hospitalization. Methods The defecation status of 128 patients with type 2 diabetes who were admitted to our department for diabetes education was evaluated for 7 days after hospitalization. New-onset constipation was diagnosed when patients without constipation before hospitalization met the criteria for constipation after hospitalization.
View Article and Find Full Text PDFIntroduction: This study investigated the relationships between changes in renal prognosis-related factors after initiating tofogliflozin and the corresponding baseline values in clinical practice in Japanese patients with type 2 diabetes.
Methods: We investigated the relationships between changes in hematocrit, hemoglobin, systolic blood pressure (sBP), urinary protein excretion (uPE), serum uric acid (sUA), and estimated glomerular filtration rate (eGFR) 12 months after initiating tofogliflozin (20 mg) and their corresponding baseline values in 130 patients with type 2 diabetes. The subjects were divided into two groups: normal (≥60 mL/min/1.
Article Synopsis
- The study examined the effectiveness of a combination therapy of insulin degludec and liraglutide (IDegLira) in managing type 2 diabetes among Japanese patients, particularly focusing on liver health as assessed by the Fibrosis-4 index (FIB-4).
- In a group of 113 patients over 6 months, both those previously treated with glucagon-like peptide-1 receptor agonists (GLP-1RA) and those who were not showed significant reductions in glycated hemoglobin, indicating improved blood sugar control.
- While weight decreased in the GLP-1RA-naïve group, it slightly increased in the GLP-1RA-treated group, and FIB-4 levels improved
Aim: The incidence of cardiovascular and renal events was investigated in patients with type 2 diabetes who were classified according to anemia and the components of dialysis-independent chronic kidney disease (CKD) in a prospective observational study.
Methods: A population of 778 Japanese patients with type 2 diabetes was prospectively analyzed for 4 years. The outcomes were the incidence of cardiovascular events and renal events.