Designing an anticancer Pd(II) complex as poly(ADP-ribose) polymerase 1 inhibitor.

Targeting DNA repair mechanisms, particularly PARP-1 inhibition, has emerged as a promising strategy for developing anticancer therapies. we designed and synthesized two 2-thiazolecarboxaldehyde thiosemicarbazone palladium(II) complexes (C1 and C2), and evaluated their anti-cancer activities. These Pd(II) complexes exhibited potent PARP-1 enzyme inhibition and demonstrated considerable antiproliferative activity against various cancer cell lines.

Synthesis and Anticancer Studies of Pt(II) Complex Derived From 4-Phenylthiosemicarbazone.

Although cisplatin is widely used as a first-line chemotherapy agent, it has significant side effects. Herein, we synthesized a Pt(II) complex (Pt1) derived from o-vanillin-4-phenylthiosemicarbazone ligand and confirmed its crystal structure by x-ray crystallography. Complex Pt1 exhibited potent anticancer activity against various tested cancer cell lines, with particular efficacy against HepG-2 cells.

SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations.

Limited whole genome sequencing (WGS) studies in Asian populations result in a lack of representative reference panels, thus hindering the discovery of ancestry-specific variants. Here, we present the South and East Asian reference Database (SEAD) panel ( https://imputationserver.westlake.

The antagonistic effects of red and blue light radiation on leaf and stem development of pepper (Capsicum annuum L.) seedlings.

Light spectrum plays an essential role in influencing the growth and development of vegetable seedlings in industrial seedling raising. Currently, blue light, red light, and their combination are utilized in industrial seedling raising. However, the theoretical basis behind the screening of red and blue light combinations remains unclear.

Error Model and Concise Temporal Network for Indirect Illumination in 3D Reconstruction.

3D reconstruction is a fundamental task in robotics and AI, providing a prerequisite for many related applications. Fringe projection profilometry is an efficient and non-contact method for generating 3D point clouds out of 2D images. However, during the actual measurement, it is inevitable to experiment with translucent objects, such as skin, marble, and fruit.