Exploring the Interactome of the Queuine Salvage Protein DUF2419 in .

causes amebiasis, a significant global health issue, with millions affected annually, especially in developing countries. EhDUF2419, an important protein involved in 's queuine salvage pathway and its interaction network, remains unclear. To explore this, we transfected trophozoites with a plasmid encoding Myc-tagged EhDUF2419 and achieved successful overexpression.

Impact of Reactive Sulfur Species on : Modulating Viability, Motility, and Biofilm Degradation Capacity.

Reactive sulfur species (RSS) like hydrogen sulfide (HS) and cysteine persulfide (Cys-SSH) emerged as key signaling molecules with diverse physiological roles in the body, depending on their concentration and the cellular environment. While it is known that HS and Cys-SSH are produced by both colonocytes and by the gut microbiota through sulfur metabolism, it remains unknown how these RSS affect amebiasis caused by , a parasitic protozoan that can be present in the human gastrointestinal tract. This study investigates HS and Cys-SSH's impact on physiology and explores potential therapeutic implications.

Unraveling the interplay between unicellular parasites and bacterial biofilms: Implications for disease persistence and antibiotic resistance.

Bacterial biofilms have attracted significant attention due to their involvement in persistent infections, food and water contamination, and infrastructure corrosion. This review delves into the intricate interactions between bacterial biofilms and unicellular parasites, shedding light on their impact on biofilm formation, structure, and function. Unicellular parasites, including protozoa, influence bacterial biofilms through grazing activities, leading to adaptive changes in bacterial communities.

Digestive exophagy of biofilms by intestinal amoeba and its impact on stress tolerance and cytotoxicity.

The human protozoan parasite Entamoeba histolytica is responsible for amebiasis, a disease endemic to developing countries. E. histolytica trophozoites colonize the large intestine, primarily feeding on bacteria.

Insights into the Role of Oxidative Stress and Reactive Oxygen Species in Parasitic Diseases.

Parasitic infections remain a significant public health challenge in many parts of the world, especially in developing countries [...