Am J Physiol Heart Circ Physiol
December 2024
Residual inflammation drives atherogenesis to atherosclerosis and myocardial infarction, which triggers acute inflammation. In preclinical studies, polyunsaturated fatty acids-derived specialized pro-resolving mediators (SPMs) have been shown to promote recovery after MI, in contrast to pro-inflammatory lipid mediators (PIMs). However, the dynamic changes of lipid mediators after ST-elevation myocardial infarction (STEMI), particularly after percutaneous coronary intervention (PCI) and respective gene transcripts, are poorly understood.
View Article and Find Full Text PDFIliopsoas abscess is a rare infection that presents with a triad of fever, back pain, and hip pain. However, due to the anatomical proximity of the psoas muscle to various structures, an abscess in this region can manifest with nonspecific symptoms, leading to potential misdiagnosis and delayed diagnosis, which can be fatal. We report a case of a 54-year-old female who presented to the emergency department with right-sided flank pain and symptoms resembling lower motor neuron disorder.
View Article and Find Full Text PDFBackground: Over a century ago, Virchow proposed that cancer represents a chronically inflamed, poorly healing wound. Normal wound healing is represented by a transitory phase of inflammation, followed by a pro-resolution phase, with prostaglandin (PGE2/PGD2)-induced 'lipid class switching' producing inflammation-quenching lipoxins (LXA4, LXB4).
Objective: We explored if lipid dysregulation in colorectal cancers (CRCs) is driven by a failure to resolve inflammation.