Increased urinary C-peptide and albumin excretion in juvenile borderline hypertensives.

The study was designed to evaluate the urinary excretion of C-peptide and albumin, and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in juvenile borderline hypertensives. The second aim was to examine the relationship between these variables and ambulatory blood pressure level and variability. The study group consisted of 21 non-obese males consecutively chosen from patients with borderline hypertension, defined by sphygmanometer readings, examined in our outpatient clinic.

Protective effect of allopurinol, alpha-tocopherol and chlorpromazine on rat pancreatic islets stored prior to transplantation.

Iso-transplantation of 800 isolated rat pancreatic islets into the portal vein of diabetic rats was performed. Isolated islets were kept in Hanks buffer for 12 hours prior to transplantation. Part of donors was pretreated with allopurinol, alpha-tocopherol and chlorpromazine.

[Transplantation of free beta islet cells as a method leading to normalization of glucose tolerance in rats with experimental diabetes].

The aim of present study was to investigate the effect of free beta cells transplantation on carbohydrate tolerance in rats with streptozotocin-induced diabetes. Free beta cells were isolated by mechanical disruption of isolated pancreatic islets in Ca and Mg free medium. 1500 and 3000 isolated islets were used for the isolation of 500 x 10(3)-1.