Publications by authors named "S Amend"
Objective: This cross-sectional study aimed to investigate the use, quality, and caries-preventive effects of fissure sealants (FSs) in 8- to 10-year-olds with and without molar-incisor hypomineralization (MIH).
Materials And Methods: A total of 5,418 children (2,692 males, 2,726 females) were examined via standard instruments (dental mirrors, CPI probes, adequate lighting, mobile examination tables, and air syringes) and methods for the recording of caries (DMFT index, WHO method) and FSs. The classification of MIH followed the recommendations of the European Academy of Pediatric Dentistry (EAPD).
Article Synopsis
- The research investigates how prostate cancer adapts to changing environments and the role of the Polyaneuploid Cancer Cell (PACC) state in metastasis, suggesting that PACC can enhance metastatic potential.
- Evidence from previous studies shows that the presence of PACC in patient tumors correlates with a higher risk of future metastasis, prompting the use of innovative methods to analyze circulating and disseminated tumor cells from animal models.
- The findings reveal that a significant majority of these tumor cells were in the PACC state, and specific traits associated with PACC contribute to its ability to spread and colonize new sites, raising concerns about the effectiveness of certain cancer treatments that may inadvertently promote metastasis.
Article Synopsis
- Therapeutic resistance in cancer, especially in advanced prostate cancer, contributes to high mortality as patients often relapse after initial treatments.
- Research on circulating tumor cells with increased genomic content (CTC-IGC) from 44 advanced prostate cancer patients reveals a link to poorer survival outcomes and clonal origins, indicating polyploidization.
- Identification of new RNA and protein markers associated with chemotherapy resistance, such as HOMER1, TNFRSF9, and LRP1, suggests pathways for improving cancer treatment and understanding relapse mechanisms.
Bystanders or active players: the role of extra centrosomes as signaling hubs.
Cancer Metastasis Rev
November 2024
Centrosomes serve as microtubule-organizing organelles that function in spindle pole organization, cell cycle progression, and cilia formation. A non-canonical role of centrosomes that has gained traction in recent years is the ability to act as signal transduction centers. Centrosome amplification, which includes numerical and structural aberrations of centrosomes, is a candidate hallmark of cancer.
View Article and Find Full Text PDFThis study delves into the proteomic intricacies of drug-resistant cells (DRCs) within prostate cancer, which are known for their pivotal roles in therapeutic resistance, relapse, and metastasis. Utilizing single-cell proteomics (SCP) with an optimized high-throughput Data Independent Acquisition (DIA) approach with the throughput of 60 sample per day, we characterized the proteomic landscape of DRCs in comparison to parental PC3 cells. This optimized DIA method allowed for robust and reproducible protein quantification at the single-cell level, enabling the identification and quantification of over 1,300 proteins per cell on average.
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