Publications by authors named "S Ambretti"
: The main aim of this study was to describe the epidemiology of infected non-unions (INUs) managed at an Infectious Disease (ID) referral centre and to investigate the factors associated with treatment failure. : This was an observational retrospective study on adult patients with INUs managed between 2012 and 2018 at the ID Unit of the IRCCS Azienda Ospedaliero-Universitaria di Bologna, an Italian ID referral centre for bone and joint infections. Patients were observed for at least 24 months.
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- The study assesses the effectiveness of new antibiotic combinations against KPC-producing Klebsiella pneumoniae (KPC-Kp) in Italy, focusing on clinical isolates from 2022-2023.
- Both meropenem/vaborbactam and imipenem/relebactam exhibited high susceptibility rates, indicating their potential as effective treatments.
- Resistance to these antibiotics is associated with specific genetic factors, including the presence of KPC gene variants and changes in porin proteins, which affect drug uptake.
Carbapenem-resistant Enterobacterales (CREs) are globally considered to be a major threat to public health. National and international guidelines emphasize the importance of routine active surveillance policies to prevent their transmission. Consequently, screening for the evaluation of the status of colonization by CREs in hospitalized patients in Italy is considered essential to contain and control the spread of these microorganisms and their evolution towards infection.
View Article and Find Full Text PDFBackground: Foodborne diseases are a major global public health concern, causing significant morbidity and mortality worldwide. The COVID-19 pandemic has had widespread effects on various aspects of life, including the food supply chain, potentially impacting the incidence of foodborne diseases. This study aims to analyze the differences between notified and diagnosed cases and investigate the potential impact of the COVID-19 pandemic on foodborne diseases in the metropolitan area of Bologna, Italy.
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- A study on perioperative antibiotic prophylaxis (PAP) in lung transplant recipients over a 20-year period revealed significant variation in practices among different centers.
- The research enrolled 111 lung transplant recipients, finding that most received combination therapy, while the median duration for PAP was 10 days.
- However, the study concluded that there was no significant difference in preventing early post-operative infections (EPOIs) between combination and single-agent therapies, and duration of PAP also did not impact EPOI rates.