Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.

Adverse events in early life can modulate the response to additional stressors later in life and increase the risk of developing psychiatric disorders. The underlying molecular mechanisms responsible for these effects remain unclear. Here, we uncover that early life adversity (ELA) in mice leads to social subordination.

Myo-Inositol Levels in the Dorsal Hippocampus Serve as Glial Prognostic Marker of Mild Cognitive Impairment in Mice.

Dementia is a devastating age-related disorder. Its therapy would largely benefit from the identification of susceptible subjects at early, prodromal stages of the disease. To search for such prognostic markers of cognitive impairment, we studied spatial navigation in male BALBc vs.

Visualization of Active Polysynaptic Circuits With Longitudinal Manganese-Enhanced MRI (MEMRI).

Manganese-enhanced magnetic resonance imaging (MEMRI) is a powerful tool for non-invasive whole-brain mapping of neuronal activity. Mn enters active neurons via voltage-gated calcium channels and increases local contrast in T-weighted images. Given the property of Mn of axonal transport, this technique can also be used for tract tracing after local administration of the contrast agent.

Mn dynamics in manganese-enhanced MRI (MEMRI): Ca1.2 channel-mediated uptake and preferential accumulation in projection terminals.

Manganese-enhanced magnetic resonance imaging (MEMRI) exploits the biophysical similarity of Ca and Mn to map the brain's activity in vivo. However, to what extent different Ca channels contribute to the enhanced signal that MEMRI provides and how Mn dynamics influence Mn brain accumulation after systemic administration of MnCl are not yet fully understood. Here, we demonstrate that mice lacking the L-type Ca channel 1.

Beware of your Cre-Ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory.

Expression of the lacZ-sequence is a widely used reporter-tool to assess the transgenic and/or transfection efficacy of a target gene in mice. Once activated, lacZ is permanently expressed. However, protein accumulation is one of the hallmarks of neurodegenerative diseases.