Novel metal-organic framework coated with chitosan-κ-carrageenan as a platform for curcumin delivery to cancer cells.

Metal-organic frameworks (MOFs) have shown great promise as pH-responsive drug delivery systems, with considerable potential for targeted cancer therapy. In this study, we synthesized a novel curcumin-loaded MOF, named UWO-2 (CUR@UWO-2), and developed its biocomposite form, CS-κ-Cr/CUR@UWO-2, by coating it with chitosan (CS) and κ-carrageenan (κ-Cr). Structural analysis through powder X-ray diffraction (PXRD) confirmed the successful synthesis of UWO-2 and the incorporation of CUR within the MOF structure.

Sacrificial MOF-derived MnNi hydroxide for high energy storage supercapacitor electrodes via DFT-based quantum capacitance study.

Electrochemical energy storage plays a critical role in the transition to clean energy. With the growing demand for efficient and sustainable energy solutions, supercapacitors have gained significant attention due to their high specific capacitance, rapid charge/discharge capabilities, long lifespan, safe operation across various temperatures, and minimal maintenance needs. This study introduces a novel approach for the synthesis of high-performance supercapacitor electrodes by using MnNi-MOF-74 as a precursor.

Development of metal-organic framework biocomposites from chitosan as drug delivery vehicles: In vitro evaluation on HeLa and SH-SY5Y cell lines.

In modern times, achieving precise drug delivery through a safe and stable carrier remains a significant challenge. In this study, we synthesized a novel ligand based on a guanazole Schiff base and subsequently developed new metal-organic framework (MOF) named UWO-1 through a reaction involving zinc acetate. At the same time, curcumin (CUR) was loaded onto the newly synthesized UWO-1.

Local Delivery of Ginger Extract a Nanofibrous Membrane Suppresses Human Skin Melanoma B16F10 Cells Growth Targeting Ras/ERK and PI3K/AKT Signaling Pathways: An Study.

Background: Metastatic melanoma poses a significant threat globally, with a distressingly low ten-year survival rate of only 10%. While FDA-approved treatments such as dacarbazine and high-dose IL-2 have been employed in clinical settings, their limitations underscore the urgent need for more effective therapies.

Aims: This study aimed to develop a potential anticancer local treatment through the extraction of various amounts of ginger extract loaded unto Poly(vinyl alcohol) (PVA) nanofibers.