Publications by authors named "S Alexiou"
Objectives: To examine the association of novel furosemide versus thiazide diuretic exposure with changes in serum sodium, potassium, and chloride levels among infants with grade 2/3 bronchopulmonary dysplasia (BPD).
Study Design: Retrospective cohort study of infants admitted to a level IV neonatal intensive care unit (NICU) with grade 2/3 BPD. We measured within-subject change in serum sodium, potassium, and chloride before and after diuretic initiation using multivariable regression to adjust for differences in dosing and clinical covariates.
Atrial fibrillation (AF) is the most prevalent arrhythmia among adults worldwide, frequently co-occurring with comorbidities such as Heart Failure (HF) and Type 2 Diabetes Mellitus (T2DM). This association contributes to increased morbidity and mortality, elevated healthcare costs, and diminished quality of life. Consequently, preventing or delaying the onset and recurrence of AF is crucial for reducing the incidence of complications.
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- The study focused on ventilator-dependent infants and children with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) to assess their health outcomes.
- Approximately 60% of the 154 subjects had pulmonary hypertension, with many requiring specific medications; those with PH tended to transition to home ventilation and discharge at older ages.
- Despite the challenges, most subjects improved over time, successfully weaning off oxygen and ventilators by age 5, with a low mortality rate after discharge.
Article Synopsis
- The study aimed to assess the link between indoor air pollution and respiratory issues in children with bronchopulmonary dysplasia (BPD) under 3 years old.
- It involved 1,011 participants, with over 40% exposed to indoor pollutants like tobacco smoke and gas stoves, revealing higher odds of emergency visits and antibiotic use associated with secondhand smoke exposure.
- While acute respiratory problems were related to indoor air pollution, chronic respiratory symptoms and rescue medication use showed no significant association.
Article Synopsis
- The study aimed to identify factors affecting when infants with severe bronchopulmonary dysplasia (sBPD) can be liberated from ventilators and successfully decannulated.
- Results showed that on average, ventilation liberation occurred at 27 months and decannulation at 49 months, with factors like age at discharge, ventilator pressure, and respiratory readmissions influencing these timings.
- Conclusions highlighted that individual factors predominantly drive the differences in timing, while aggressive management of gastroesophageal reflux affected decannulation timelines.