Publications by authors named "S Alexandra Garcia-Moreno"
Article Synopsis
- Midbrain dopamine neurons loss is a key feature of Parkinson's disease (PD), and the protein α-synuclein is linked to this condition but its role in neuronal vulnerability is unclear.
- Researchers developed a new viral vector to selectively overexpress human α-synuclein in specific neuron types, particularly focusing on dopamine neurons in the substantia nigra pars compacta (SNc).
- Increased levels of α-synuclein led to some pathological changes but surprisingly resulted in greater dopamine activity without causing neurodegeneration in these neurons over a 90-day period.
Article Synopsis
- The study explores the genetic factors behind autism spectrum disorder by focusing on specific risk genes and their interactions within protein complexes in the mouse brain.
- Researchers developed a method to examine the spatial proteomes of these genes, identifying interactions that connect high-risk genes with less-known ones, which may help in prioritizing genetic risks.
- By using spatial proteomics and CRISPR technology, the study demonstrates functional interactions that regulate gene expression, shedding light on cellular mechanisms involved in autism and offering new pathways for research and potential treatments.
Members of the Iroquois B (IrxB) homeodomain cluster genes, specifically and , are crucial for heart, limb and bone development. Recently, we reported their importance for oocyte and follicle survival within the developing ovary. and expression begins after sex determination in the ovary but remains absent in the fetal testis.
View Article and Find Full Text PDFBackground: Postoperative intussusception is an unusual complication in children; the incidence is 0.01-0.25%.
View Article and Find Full Text PDFXX and XY fetal gonads are initially bipotential, poised between the ovary and testis fate. Multiple lines of evidence suggest that commitment to testis fate requires the repression of genes associated with ovary fate. It was previously shown that loss of CBX2, the subunit of the Polycomb Repressive Complex 1 (PRC1) that binds H3K27me3 and mediates silencing, leads to ovary development in XY mice and humans.
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