Publications by authors named "S Albinni"
Evaluation of bone mineral density and bone turnover in children on anticoagulation.
Front Endocrinol (Lausanne)
August 2023
Article Synopsis
- Childhood and adolescence are crucial for bone mineral acquisition, and children on anticoagulation (AC) may have a higher risk of reduced bone mineral density (BMD) due to factors like chronic diseases and vitamin deficiencies.
- The study aimed to assess BMD in children on AC and identify risk factors related to low BMD, focusing on vitamin K (VK) and vitamin D (VD) levels.
- Results showed decreased BMD in children on AC, with significant links between early pubertal development, BMI, and BMD, but AC-related factors did not predict low BMD; awareness of vitamin deficiencies during puberty is essential for improving bone health in affected children.
Background: Pulmonary hypertension (PH) is a severe hemodynamic condition with high morbidity and mortality. Approved targeted therapies are limited for pediatric subjects, and treatments are widely adopted from adult algorithms. Macitentan is a safe and effective drug used for adult PH, but data on pediatric patients are limited.
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- Long-term multilineage hematopoietic donor chimerism is a rare occurrence in patients receiving solid organ transplants, particularly those from lymphoid-rich organs like the intestine or liver.
- Unlike other organs, there has been no evidence of kidney-resident hematopoietic stem cells in mammals, but new findings suggest they may exist.
- A case study of a pediatric kidney transplant recipient indicates that these kidney-derived stem cells can reside in bone marrow long-term, ultimately replacing the host's stem cells and achieving full donor chimerism in blood lineages.
Macitentan is a safe and effective substance for treatment of adults with pulmonary arterial hypertension. Data on its use in paediatric patients are limited. In this single-centre prospective study, we report on our experience with macitentan in children focusing on applicability and practical aspects.
View Article and Find Full Text PDFPulmonary hypertensive vascular disease (PHVD), and pulmonary hypertension (PH), which is a broader term, are severe conditions associated with high morbidity and mortality at all ages. Treatment guidelines in childhood are widely adopted from adult data and experience, though big differences may exist regarding aetiology, concomitant conditions and presentation. Over the past few years, paediatric aspects have been incorporated into the common guidelines, which currently address both children and adults with pulmonary hypertension (PH).
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